The Haskell-Luevano Research Lab

Welcome to the Haskell-Luevano group website. Our research group is interested in the understanding of G protein-coupled receptors (GPCRs) and their involvement in feeding behavior, exercise, diabetes, and obesity.
 
We utilize multidisciplinary approaches including organic chemistry, chemical biology, biochemistry, molecular biology, pharmacology, physiology, animal studies, and neuroscience to study endocrine systems. A summary of the key elements of our research program along with relevant references can be found in the links below.        

Photo of organic medicinal chemistry

Design and synthesis of templates based on small molecules, peptides and peptidomimetics. The synthetic strategies involve solid-phase peptide synthesis using automated, semi-automated, manual and microwave synthesizers and multi-step organic synthesis. The lead identification and structure-activity studies generally use focused-library design or high throughput screening approaches.

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Photo of G Protein-Coupled Receptor Molecular Pharmacology

The in vitro pharmacology of the compounds are established using functional bio-assays, binding, mutagenesis and pharmacokinetic studies. This provide the structural basis for ligand binding and activation, novel allosteric sites distinct from the orthosteric site, and ligand-directed differential signaling and regulation of receptors.

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Photo of neuroscience

The Haskell-Luevano lab uses a variety of neuroscience techniques in order to examine neurotropic changes in the brain.

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Photo of In Vivo Studies

The Haskell-Luevano laboratory uses in vivo models to examine how melanocortin-specific drugs effect metabolic diseases.

After a drug is created, in vivo studies are performed in order to help verify the safety and effectiveness of the drug.

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